VTE – Pharmacotherapeutics Study Guide Pharmacotherapeutics III · PharmD Year 4 Venous Thromboembolism Deep Vein Thrombosis (DVT) & Pulmonary Embolism (PE) — Complete Exam Guide 01 Definition & Overview Venous Thromboembolism (VTE) is a spectrum of disease encompassing: • Deep Vein Thrombosis (DVT) — formation of a blood clot (thrombus) within the deep veins, most commonly the proximal leg veins (femoral, popliteal, iliac). • Pulmonary Embolism (PE) — migration of a DVT clot to the pulmonary vasculature, causing obstruction. Can be life-threatening. VTE is the 3rd most common cardiovascular disorder after MI and stroke, with ~1–2 cases per 1,000 person-years. 02 Pathophysiology — Virchow's Triad 🩸 Hypercoagulability Factor V Leiden, Protein C/S deficiency, antiphospholipid syndrome, OCP use, malignancy ...
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